LISE – Long-term immune responsiveness of senior individuals to SARS-CoV-2
Project leader: Prof. Dr. Jochen Hühn
Key areas
- Antiviral strategies: agents and vaccines, antibodies
- Pathophysiology: immunmodulation and immune control
- Digital infectious medicine: individualised patient care
Who is involved?
- Prof. Dr. Jochen Hühn (Project leader, HZI)
- Prof. Dr. Reinhold Förster (MHH)
- Prof. Dr. Yang Li, (HZI, CiiM)
- Prof. Dr. Thomas Illig (HUB)
- Prof. Dr. Stefan Pöhlmann (DPZ)
- Dr. Lennart Rösner (MHH)
- Prof. Dr. med. Thomas Werfel (MHH)
What is the aim?
Senior individuals are particularly susceptible to infection with SARS-CoV-2 and are at higher risk for a more severe course of COVID-19. Despite some important recent findings, the underlying molecular mechanisms are not yet well understood. In this project, we aim to investigate the strength and duration of the cellular and humoral immune response of elderly individuals from Lower Saxony recruited within the Senior Individuals Cohort of the RESIST Cluster of Excellence, as well as the dynamics of the decline of this immune response using multi-omics analyses to generate a comprehensive picture of the immune response of elderly individuals against SARS-CoV-2.
Publications
- Altered and allele-specific open chromatin landscape reveals epigenetic and genetic regulators of innate immunity in COVID-19. Zhang, B., Zhang, Z., Koeken, V.A.C.M., Kumar, S., Aillaud, M., Tsay, H.-C., Liu, Kraft, A.R.M., Soon, C.F., Odak, I., Bošnjak, B., Vlot, A., Deutsche COVID-19 OMICS Initiative (DeCOI), Swertz, M.A., Ohler, U., Geffers, R., Illig, T., Huehn, J., Saliba, A.E., Sander, L.E., Förster, R., Xu, C.-J., Cornberg, M., Schulte, L.N., Li, Y. Cell Genomics, December 2, 2022. https://doi.org/10.1016/j.xgen.2022.100232