Immunothrombosis in cerebrovascular complications related to SARS-CoV-2 infection and vaccine-induced immune thrombotic thrombocytopenia (ISI-VITT)
Project leader: Dr. Nicole de Buhr
Key area
- Pathophysiology: immunmodulation and immune control
Who is involved?
- Dr. Nicole de Buhr (Project leader, TiHo)
- Dr. med. Ramona Schuppner (MHH)
- Dr. med. Gerrit Grosse (MHH)
What is the aim?
The aim of this interdisciplinary study is to elucidate the role of DNA networks (NETs) in cerebrovascular complications due to COVID-19 disease or VITT following the use of vaccines against SARS-CoV-2. Our aim is to identify the processes underlying the pathophysiology of immunothrombosis, which could ultimately lead to potential diagnostic and therapeutic targets.
Publications
- Insights into immunothrombotic mechanisms in acute stroke due to vaccine-induced immune thrombotic thrombocytopenia. Nicole de Buhr , Tristan Baumann, Christopher Werlein, Leonie Fingerhut, Rabea Imker, Marita Meurer, Friedrich Goetz, Paul Bronzlik, Mark Philipp Kühnel, Danny Jonigk, Johanna Ernst, Andrei Leotescu, Maria M. Gabriel, Hans Worthmann, Ralf Lichtinghagen, Andreas Tiede, Maren von Köckritz-Blickwede, Christine Susanne Falk, Karin Weissenborn, Ramona Schuppner and Gerrit M. Grosse. Front. Immunol., 10 May 2022 | https://doi.org/10.3389/fimmu.2022.879157