Publications of RTG 2824 PhD Students

Cleophas Cheruiyot (RP5 Ebert/Zimmermann)

Wali R, Xu H, Cheruiyot C, Saleem HN, Janshoff A, Habeck M, Ebert A. Integrated machine learning and multimodal data fusion for patho-phenotypic feature recognition in iPSC models of dilated cardiomyopathy. Biol Chem. 2024 Apr 24;405(6):427-439 DOI: 10.1515/hsz-2024-0023. Print 2024 Jun 25. PMID: 38651266

Anastasiia A. Gorshkova (RP1 Lehnart/Lenz)

Paulke NJ, Fleischhacker C, Wegener JB, Riedemann GC, Cretu C, Mushtaq M, Zaremba N, Möbius W, Zühlke Y, Wedemeyer J, Liebmann L, Gorshkova AA, Kownatzki-Danger D, Wagner E, Kohl T, Wichmann C, Jahn O, Urlaub H, Toischer K, Hasenfuß G, Moser T, Preobraschenski J, Lenz C, Rog-Zielinska EA, Lehnart SE, Brandenburg S. Dysferlin Enables Tubular Membrane Proliferation in Cardiac Hypertrophy. Circ Res. 2024 Aug 16;135(5):554-574 DOI: 10.1161/CIRCRESAHA.124.324588. Epub 2024 Jul 16. PMID: 39011635

Publications of RTG 2824 Associated PhD/MD/Dr. med. Students

Aishwarya Bhonsle (RPA1 Wilke)

Wise DL, Escobedo-Lozoya Y, Valakh V, Isaac B, Gao EY, Greene SB, Bhonsle A, Lei QL, Cheng X, Hooser SDV and Nelson SB. Prolonged activity-deprivation causes pre- and postsynaptic compensatory plasticity at neocortical excitatory synapses. eNeuro. 2024 Jun 7;11(6):ENEURO.0366-23.2024 DOI: 10.1523/ENEURO.0366-23.2024. Print 2024 Jun. PMID: 38777611

Luca Büschgens (RPA2 Wirths)

Kaji S, Berghoff SA, Spieth L, Schlaphoff L, Sasmita AO, Vitale S, Büschgens L, Kedia S, Zirngibl M, Nazarenko T, Damkou A, Hosang L, Depp C, Kamp F, Scholz P, Ewers D, Giera M, Ischebeck T, Wurst W, Wefers B, Schifferer M, Willem M, Nave KA, Haass C, Arzberger T, Jäkel S, Wirths O, Saher G, Simons M. Apolipoprotein E aggregation in microglia initiates Alzheimer’s disease pathology by seeding β-amyloidosis. Immunity. 2025 14;58(1):263. doi: 10.1016/j.immuni.2024.11.024. Epub 2024 Dec 4. PMID: 39419029

Schrempel S,  Kottwitz AK, Piechotta A, Gnoth K, Büschgens L, Hartlage-Rübsamen M, Morawski M, Schenk M, Kleinschmidt M, Serrano GE, Beach TG, Rostagno A, Ghiso J, Heneka MT, Walter J, Wirths O, Schilling S, Roßner S. Identification of isoAsp7-Aβ as a major Aβ variant in Alzheimer's disease, dementia with Lewy bodies and vascular dementia. Acta Neuropathol. 2024 Dec 3;148(1):78. DOI: 10.1007/s00401-024-02824-9. PMID: 39625512

Büschgens L, Lauer A., Janitschke D, Grimm M.O.W., Wirths O. (2024) Caffeine and potential use in Alzheimer’s disease. Preedy V.R. (ed.) Coffee in Health and Disease Prevention, 2^nd Edition, Elsevier, Hardback ISBN: 9780443138683 (eBook ISBN: 9780443138690). 

Bader AS, Gnädig MU, Fricke M, Büschgens L, Berger LJ, Klafki HW, Meyer T, Jahn O, Weggen S and Wirths O. Brain Region-Specific Differences in Amyloid-β Plaque Composition in 5XFAD Mice. Life (Basel). 2023;13 DOI: 10.3390/life13041053. PMID: 37109582

Merle Fricke (A4 Wirths)

Wirths O, Lehnen C, Fricke M, Talucci I, Klafki H-W, Morgado B, Lehmann S, Münch C, Liepold T, Wiltfang J, Rostagno A, Ghiso J, Maric HM, Jahn O, Weggen S. Amino-terminally elongated Aβ peptides are generated by the secreted metalloprotease ADAMTS4 and deposit in a subset of Alzheimer's disease brains. Neuropathol Appl Neurobiol. 2024 Jun;50(3):e12991 DOI: 10.1111/nan.12991. PMID: 38867123

Bader AS, Gnädig MU, Fricke M, Büschgens L, Berger LJ, Klafki HW, Meyer T, Jahn O, Weggen S and Wirths O. Brain Region-Specific Differences in Amyloid-β Plaque Composition in 5XFAD Mice. Life (Basel). 2023;13 DOI: 10.3390/life13041053. PMID: 37109582

Verena Gisa (A5 Ebert)

This is a preprint. It has not yet been peer reviewed by a journal. The National Library of Medicine is running a pilot to include preprints that result from research funded by NIH in PMC and PubMed.

https://pubmed.ncbi.nlm.nih.gov/39005272: Schröder S, Fuchs U, Gisa V, Pena T, Krüger DM, Hempel N, Burkhardt S, Salinas G, Schütz A-L, Delalle I, Sananbenesi F, Fischer A. PRDM16-DT: A Brain and Astrocyte-Specific lncRNA Implicated in Alzheimer's Disease. bioRxiv [Preprint]. 2024 Jul 1:2024.06.27.600964. doi: 10.1101/2024.06.27.600964. 

Mansi Rajput (A7 von Arnim)

Rajput M, Malik IA, MEthi A., Cortés Silva JA, Fey D, Wirths O, Fischer A, Wilting J, von Arnim CAF. Cognitive decline and neuroinflammation in a mouse model of obesity: an accelerating role of ageing. Brain Behav Immun. 2024 Dec 25:S0889-1591(24)00883-3 DOI: 10.1016/j.bbi.2024.12.154. Online ahead of print. PMID: 39730092

Svenja T. Zihsler (A8 Wilke)

Martinez HA, Koliesnik I, Kaber G, Reid JK, Nagy N, Barlow G, Falk BA, Medina CO, Hargil A, Zihsler S, Vlodavsky I, Li JP, Pérez-Cruz M, Tang SW, Meyer EH, Wrenshall LE, Lord JD, Garcia KC, Palmer TD, Steinman L, Nepom GT, Wight TN, Bollyky PL and Kuipers HF. Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue. Nat Commun. 2024;15:1564 DOI: 10.1038/s41467-024-45012-9. PMID: 38378682